274 papers
This study constructs a high-resolution 4D spatiotemporal transcriptomic map of planarian regeneration using Stereo-seq, revealing dynamic morphogenetic gradients and identifying an injury-induced Anterior Regenerative Zone regulated by Mediator 8 that orchestrates polarity remodeling and blastema formation.
This paper introduces IRIS, an integrated experimental-computational framework that leverages high-throughput in vitro perturbation screens and transfer learning to accurately reconstruct in vivo single-cell signaling histories, revealing combinatorial signaling codes and accelerating stem cell differentiation optimization.
This study demonstrates that medaka ocular organoids can achieve a functional lens-retina structure through an alternative "inside-out" morphogenesis pathway driven by BMP and FGF signaling, revealing that self-organization in unconstrained environments can bypass the embryonic "outside-in" constraints while still producing similar structural outcomes.
This study on growing rats demonstrates that transverse maxillary constriction induces nasal floor slanting and mandibular shifts, which subsequently cause nasal septal deviation, whereas maxillary expansion does not produce similar deformities.
This longitudinal study of nearly 12,000 preadolescents identifies a robust latent brain morphological pattern—characterized by larger cortical surface area and volume—that serves as a transdiagnostic vulnerability-resilience continuum, where lower scores predict the presence, severity, and persistence of psychiatric disorders while higher scores correlate with cognitive strength and mental health stability.
This study demonstrates that Chiari II brain malformation arises secondary to open spina bifida rather than from shared genetic factors, as evidenced by Cdx2cre-mediated Pax3 deletion in mice which induced spina bifida and subsequent Chiari II features in an otherwise genetically intact brain.
This study identifies HSD17B7 as an essential gene for sensory hair cell function and hearing, demonstrating that its deficiency disrupts cholesterol biosynthesis and subcellular localization, leading to profound sensorineural hearing loss.
This study elucidates the role of the intellectual disability risk gene RFX4 in human cortical development, demonstrating that it restrains neurogenesis by cooperating with NOTCH signaling to repress neuronal differentiation and synaptic gene expression, while also revealing distinct pathogenic mechanisms for deficiency versus specific DNA-binding domain mutations.
This study demonstrates that in Drosophila ovaries, a TGF-β signaling gradient regulates epithelial permeability by cell-autonomously suppressing tricellular junction patency through the reinforcement of E-Cadherin-based adhesion, a mechanism that operates independently of actomyosin contractility.
This study demonstrates that the novel C-terminus created by frameshift mutations in DVL1 causes Robinow Syndrome by exerting a dominant-negative effect that mislocalizes the protein to the nucleus, thereby disrupting WNT signaling and craniofacial development.
This study presents a high-resolution temporal single-cell RNA sequencing atlas of mouse nasal development from E10.5 to E18.5, identifying 52 molecularly defined cell subtypes and revealing key regulatory mechanisms and lineage transitions that govern the formation of distinct respiratory and olfactory regions.
This study demonstrates that while Hox gene expression differences do not constitute an absolute barrier to regeneration across Drosophila compartments or segments, specific genetic backgrounds like postbithorax can occasionally impose non-specific regenerative limits.
This paper proposes a revised expansion-repression feedback motif that accommodates position-dependent expander concentrations, demonstrating that such spatial variation enhances morphogen gradient scaling and robustness across entire developing tissues rather than just at single locations.